Relación entre la grasa del epicardio y la enfermedad coronaria
Hemos publicado en el Journal of Translational Medicine este estudio sobre la relación entre la grasa del epicardio y la enfermedad coronaria. Gracias al grupo liderado por la Dra. Moreno Santos, en el que estoy orgulloso de estar incluido.
Moreno-Santos I, Pérez-Belmonte LM, Macías-González M, Mataró MJ, Castellano D, López-Garrido M, Porras.Martín C. et al.
Journal of Translational Medicine;2016 Aug 13;:1–9.
Abstract
Background
Aunque estudios recientes indican que la grasa epicárdica expresa genes como los PGC1α, UCP1 y PRDM16, la asocianción de estos genes con la diabetes mellitus tipo 2 en la enfermedad coronaria sigue siendo una incógnita.
«Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown.»
Methods
PGC1α, UCP1, and PRDM16 mRNAs expression levels were measured by real-time PCR in epicardial and thoracic subcutaneous adipose tissue from 44 CAD patients (22 with DM2 [CAD-DM2] and 22 without DM2 [CAD-NDM2]) and 23 non-CAD patients (NCAD).
Results
The CAD-DM2 patients had significantly lower PGC1α and UCP1 expression in epicardial adipose tissue than the CAD-NDM2 and NCAD patients. However, PGC1α and UCP1 mRNA trended upward in subcutaneous adipose tissue from CAD-DM2 patients. At multiple regression analysis, age, body mass index, left ventricular ejection fraction, UCP1 expression of epicardial adipose tissue and diabetes came out to be independent predictors of PGC1α levels. Epicardial adipose tissue PGC1α expression was dependent on the number of injured coronary arteries and logistic regression analysis showed that PGC1α expression in epicardial adipose tissue could exert a protective effect against coronary lesions.
Conclusions
La diabetes mellitus tipo2 se asocia con una expresión disminuida de los ARN mensajeros de PGC1α y UCP1 en la grasa epicárdica de pacientes con enfermedad coronaria, probablemente reflejando la pérdida de características típicas de la grasa parda. La expresiñon disminuida de PGC1α en la grasa epicárdica humana se asocia con una mayor prevalencia de lesiones coronarias.
«DM2 is associated with decreased expression of PGC1α and UCP1 mRNA in epicardial adipose tissue of patients with CAD, likely reflecting a loss of brown-like fat features. Decreased expression of PGC1α in human epicardial adipose tissue is associated with higher prevalence of coronary lesions.»
